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National Center for Biotechnology InformationU. Table 3 Intervention effects on cognition—sub-group analyses by baseline MRI measures. These participants were selected from the most recently recruited individuals when MRI resources became available at each site, and if there were no contraindications [ 5 ]. The control group received regular health advice according to established guidelines. Alzheimers Dement. The method is based on the expectation—maximization EM algorithm, and the segmentation was done in three steps: 1 segment WM in two classes from T1 images, representing hypointense WM regions and normal bright WM regions; 2 using the results of the previous step as an initialization, segment the FLAIR images to three classes: CSF, normal brain tissue, and hyperintense voxels; and 3 using the results of the previous step as an initialization, segment the WM and subcortical regions from the FLAIR images in two classes. Zero-skewness log transformation was applied to skewed NTB components. Of the participants, were re-scanned in connection with the month visit, and all scans passed quality control Fig. Hypertension: current care summary.

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    The FINGER trial protocol [ 13 ], recruitment process [ 14 ], and primary findings [ 12 ] have been previously described in detail. Table 2 MRI measures at baseline, follow-up, and annual rate of change. An extended version of the neuropsychological test battery NTB [ 27 ] was used for cognitive assessments at baseline and month and month visits.

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    Validity of the trail making test as an indicator of organic brain damage. Hypertension: current care summary. Many observational studies have linked modifiable lifestyle, vascular, or metabolic risk factors individually and also multifactorial risk profiles with structural brain changes relevant for cognitive decline and dementia, such as brain atrophy and white matter lesions WML [ 3 — 5 ].

    MRI measures included regional brain volumes, cortical thickness, and white matter lesion WML volume.

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    This was the first prevention trial to select participants using a validated dementia risk score based on several modifiable risk factors [ 18 ]. The control group received regular health advice according to established guidelines. AD signature cortical thickness: cortical thickness in AD signature regions calculated as the average of cortical thickness in entorhinal, inferior temporal, middle temporal and fusiform regions as previously described [ 38 ].

    Pauliina Pippola, Email: if. Only few lifestyle-based trials have so far included brain MRI markers.

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    The hypothesis was that the intervention may slow down atrophy and WML progression. Trial registration ClinicalTrials. Riitta Parkkola, Email: if.

    Hypertension: current care summary. Random effects of the models were variances and covariance of individual-level intercept and slope.

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    London: Psychological Corporation Ltd;

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    A neuropsychological test battery for use in Alzheimer disease clinical trials.

    Regular phantom scans were performed, and quantitative measures of signal-to-noise ratio, uniformity, and geometric distortion were carried out at each site. National Nutrition Council. Differences between the intervention and control groups in change in MRI outcomes were investigated using FreeSurfer, and false discovery rate FDR correction for multiple comparisons was applied. The nutrition componentbased on the Finnish Nutrition Recommendations [ 21 ], included individual and group sessions supervised by study nutritionists.

    Risk score for the prediction of dementia risk in 20 years among middle aged people: a longitudinal, population-based study.

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    London: Psychological Corporation Ltd; MK, HS, and AS took part in the study supervision and coordination and obtained funding for the study. Exercise training increases size of hippocampus and improves memory. Characteristics of the intervention and control groups participants with baseline MRI measurements.

    Brain volumes were normalized by the total intracranial volume TIV to account for between-person variations in head size [ 35 ]. The FINGER trial has several pre-specified sub-group analyses [ 13 ], and in addition, the present post hoc results for four MRI measures and four cognitive outcomes were not corrected for multiple testing.

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    Table 3 Intervention effects on cognition—sub-group analyses by baseline MRI measures. This may have contributed to the lack of significant differences in MRI changes between the intervention and control groups.

    Chicago: Skoelting; PLoS One.

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    To extract reliable volume and thickness estimates for longitudinal analysis, these images were automatically processed with the longitudinal stream [ 34 ] in FreeSurfer. Group allocation was not actively disclosed to participants, who were also advised not to discuss the intervention during the testing sessions.